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How did you prepare yourself for those nude scenes, having not dealt with that before? It was more provocative and it was a risk, it was scary. Isles isn’t an adult, but I felt like we were reaching into kind of deeper waters here, in terms of adult territory, and what we were playing with. It was edgy, it was sexy and different in the sense that, you know, not to say that Dr. She fascinated me, and I liked that you didn’t know she was in an open marriage. They were concerned initially that I wouldn’t do the nudity and when I said I would, it became a deeper conversation about this woman. When this came up I wanted to understand the character further, so I got on the phone with the producers of the show and we spoke about the character and who she was. I think it’s so much fun and so wild that it was exactly what I wanted to do. Yes, from the beginning, so it was exciting when they called me to be a part of it. Of the role she says, “I really wanted to do something that was a complete departure for me.” As the boundary-pushing Runyon, Alexander embraces nudity, an older woman/ younger man relationship and an open marriage. Isles’ lab coat to pursue the role of Helene Runyon in Shameless. Sasha Alexander, a mainstay of TNT’s Rizzoli & Isles, has temporarily tossed aside Dr.